{"version":1,"kind":"Article","sha256":"","slug":"239","location":"","dependencies":[],"frontmatter":{"title":"SupT1 Cell Infusion as an HIV cure ","abstract":"In a previous in vitro study, the SupT1 cell line was explored as a decoy target for HIV-1, proposing SupT1 cell infusion as a possible cell-based therapy for HIV. In the present work, the previous in vitro model was translated into an in vivo setting. Specifically, Hu-PBMC BRGS mice were infected with a high input of HIV-1 LAI (100,000 TCID50), and 40 million 30 Gy-irradiated SupT1 cells were infused weekly for 4 weeks as a therapy. Blood samples were taken to monitor CD4+ T cell count and viral load, and mice were monitored daily for signs of illness. At the earliest time point analyzed (Week 1), there was a significantly lower plasma viral load (~10-fold) in all animals treated with SupT1 cell infusion, associated with a higher CD4+ T cell count. At later time points, infection proceeded with robust viral replication and evident CD4+ T cell depletion, except in one mouse that showed complete suppression of viral replication and preservation of CD4+ T cell count. No morbidity or mortality was associated with SupT1 cell infusion. The interesting tendencies observed in the generated data suggest that this approach should be further investigated as a possible cell-based HIV therapy.","license":"CC BY","keywords":[],"authors":[],"date_submitted":"2024-07-12T22:43:48.000Z","external_publication_id":239,"revision_cids":["bafkreibj4lzkysx5poxqnblmw7llxccqetsl6hkwsp3djokuoe4fdkfi2y","bafkreicyfh4xnhodppgb57xjetltjewmqemu34gh7oft4b4qgf6cn5u6ry"]},"mdast":{"type":"root"},"references":{"cite":{"order":[]},"data":{}}}